Glycosylation of Specific Notch EGF Repeats by O-Fut1 and Fringe Regulates Notch Signaling in Drosophila

Fringe glycosyltransferases differentially modulate the binding of Notch receptors to Delta/DLL versus Serrate/Jagged ligands by adding GlcNAc to O-linked fucose on Notch epidermal growth factor-like (EGF) repeats. Although Notch has 22 O-fucosylation sites, the biologically relevant sites affecting...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Pandey, Ashutosh, Harvey, Beth M., Lopez, Mario F., Ito, Atsuko, Haltiwanger, Robert S., Jafar-Nejad, Hamed
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6866671/
https://ncbi.nlm.nih.gov/pubmed/31722217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.027
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