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Mutual Inactivation of Notch Receptors and Ligands Facilitates Developmental Patterning

Developmental patterning requires juxtacrine signaling in order to tightly coordinate the fates of neighboring cells. Recent work has shown that Notch and Delta, the canonical metazoan juxtacrine signaling receptor and ligand, mutually inactivate each other in the same cell. This cis-interaction gen...

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Autori principali: Sprinzak, David, Lakhanpal, Amit, LeBon, Lauren, Garcia-Ojalvo, Jordi, Elowitz, Michael B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111533/
https://ncbi.nlm.nih.gov/pubmed/21695234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002069
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