A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In vitro and In vivo

Using a high throughput screening (HTS) approach, we have identified and validated several small molecule Mcl-1 inhibitors (SMIs). Here we describe a novel selective Mcl-1 SMI inhibitor, 2 (UMI-77), developed by structure-based chemical modifications of the lead compound 1 (UMI-59). We have characte...

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Main Authors: Abulwerdi, Fardokht, Liao, Chenzhong, Liu, Meilan, Azmi, Asfar S., Aboukameel, Amro, Mady, Ahmed S.A., Gulappa, Thippeswamy, Cierpicki, Tomasz, Owens, Scott, Zhang, Tao, Sun, Duxin, Stuckey, Jeanne A., Mohammad, Ramzi M., Nikolovska-Coleska, Zaneta
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174574/
https://ncbi.nlm.nih.gov/pubmed/24019208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0767
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