Inhibition of phosphodiesterase 5 restores endothelial function in renovascular hypertension

BACKGROUND: The clipping of an artery supplying one of the two kidneys (2K1C) activates the renin-angiotensin (Ang) system (RAS), resulting in hypertension and endothelial dysfunction. Recently, we demonstrated the intrarenal beneficial effects of sildenafil on the high levels of Ang II and reactive...

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Detalles Bibliográficos
Main Authors: Dias, Ananda T, Cintra, Amanda S, Frossard, Jéssica C, Palomino, Zaira, Casarini, Dulce E, Gomes, Isabele BS, Balarini, Camille M, Gava, Agata L, Campagnaro, Bianca P, Pereira, Thiago MC, Meyrelles, Silvana S, Vasquez, Elisardo C
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172908/
https://ncbi.nlm.nih.gov/pubmed/25223948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0250-x
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