Inhibition of phosphodiesterase 5 restores endothelial function in renovascular hypertension

BACKGROUND: The clipping of an artery supplying one of the two kidneys (2K1C) activates the renin-angiotensin (Ang) system (RAS), resulting in hypertension and endothelial dysfunction. Recently, we demonstrated the intrarenal beneficial effects of sildenafil on the high levels of Ang II and reactive...

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Bibliografiska uppgifter
Huvudupphovsmän: Dias, Ananda T, Cintra, Amanda S, Frossard, Jéssica C, Palomino, Zaira, Casarini, Dulce E, Gomes, Isabele BS, Balarini, Camille M, Gava, Agata L, Campagnaro, Bianca P, Pereira, Thiago MC, Meyrelles, Silvana S, Vasquez, Elisardo C
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172908/
https://ncbi.nlm.nih.gov/pubmed/25223948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0250-x
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