Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity

BACKGROUND: Therapeutic blood plasma concentrations of anti-malarial drugs are essential for successful treatment. Pharmacokinetics of pharmaceutical compounds are dependent of adsorption, distribution, metabolism, and excretion. ATP binding cassette (ABC) transport proteins are particularly involve...

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Bibliographic Details
Main Authors: Rijpma, Sanna R, van den Heuvel, Jeroen JMW, van der Velden, Maarten, Sauerwein, Robert W, Russel, Frans GM, Koenderink, Jan B
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172838/
https://ncbi.nlm.nih.gov/pubmed/25218605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-13-359
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