The feline bile salt export pump: a structural and functional comparison with canine and human Bsep/BSEP

BACKGROUND: The bile salt export pump (BSEP/ABCB11) is the primary transporter for the excretion of bile acids from hepatocytes into bile. In human, inhibition of BSEP by drugs has been related to drug-induced cholestasis and subsequent cytotoxic effects. The role of BSEP in canine and feline liver...

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Main Authors: van Beusekom, Cyrina D, van den Heuvel, Jeroen JMW, Koenderink, Jan B, Schrickx, Johannes A, Russel, Frans GM
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900472/
https://ncbi.nlm.nih.gov/pubmed/24359682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1746-6148-9-259
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