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Structure based classification for bile salt export pump (BSEP) inhibitors using comparative structural modeling of human BSEP
The bile salt export pump (BSEP) actively transports conjugated monovalent bile acids from the hepatocytes into the bile. This facilitates the formation of micelles and promotes digestion and absorption of dietary fat. Inhibition of BSEP leads to decreased bile flow and accumulation of cytotoxic bil...
Kaydedildi:
| Yayımlandı: | J Comput Aided Mol Des |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Springer International Publishing
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5487762/ https://ncbi.nlm.nih.gov/pubmed/28527154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-017-0021-x |
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