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Structure based classification for bile salt export pump (BSEP) inhibitors using comparative structural modeling of human BSEP

The bile salt export pump (BSEP) actively transports conjugated monovalent bile acids from the hepatocytes into the bile. This facilitates the formation of micelles and promotes digestion and absorption of dietary fat. Inhibition of BSEP leads to decreased bile flow and accumulation of cytotoxic bil...

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Vydáno v:J Comput Aided Mol Des
Hlavní autoři: Jain, Sankalp, Grandits, Melanie, Richter, Lars, Ecker, Gerhard F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487762/
https://ncbi.nlm.nih.gov/pubmed/28527154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-017-0021-x
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