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Structure based classification for bile salt export pump (BSEP) inhibitors using comparative structural modeling of human BSEP

The bile salt export pump (BSEP) actively transports conjugated monovalent bile acids from the hepatocytes into the bile. This facilitates the formation of micelles and promotes digestion and absorption of dietary fat. Inhibition of BSEP leads to decreased bile flow and accumulation of cytotoxic bil...

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Dades bibliogràfiques
Publicat a:J Comput Aided Mol Des
Autors principals: Jain, Sankalp, Grandits, Melanie, Richter, Lars, Ecker, Gerhard F.
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487762/
https://ncbi.nlm.nih.gov/pubmed/28527154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-017-0021-x
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