Inhibitory Potential of Antifungal Drugs on ATP-Binding Cassette Transporters P-Glycoprotein, MRP1 to MRP5, BCRP, and BSEP

Inhibition of ABC transporters is a common mechanism underlying drug-drug interactions (DDIs). We determined the inhibitory potential of antifungal drugs currently used for invasive fungal infections on ABC transporters P-glycoprotein (P-gp), MRP1 to MRP5, BCRP, and BSEP in vitro. Membrane vesicles...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Lempers, Vincent J. C., van den Heuvel, Jeroen J. M. W., Russel, Frans G. M., Aarnoutse, Rob E., Burger, David M., Brüggemann, Roger J., Koenderink, Jan B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879353/
https://ncbi.nlm.nih.gov/pubmed/27001813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02931-15
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