A genomics approach identifies senescence-specific gene expression regulation

Replicative senescence is a fundamental tumor-suppressive mechanism triggered by telomere erosion that results in a permanent cell cycle arrest. To understand the impact of telomere shortening on gene expression, we analyzed the transcriptome of diploid human fibroblasts as they progressed toward an...

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Bibliografske podrobnosti
Main Authors: Lackner, Daniel H, Hayashi, Makoto T, Cesare, Anthony J, Karlseder, Jan
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2014
Teme:
Short Takes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172521/
https://ncbi.nlm.nih.gov/pubmed/24863242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12234
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