IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell–dependent antigen

The importance of IκB kinase (IKK)–induced proteolysis of NF-κB1 p105 in B cells was investigated using Nfkb1(SSAA/SSAA) mice, in which this NF-κB signaling pathway is blocked. Nfkb1(SSAA) mutation had no effect on the development and homeostasis of follicular mature (FM) B cells. However, analysis...

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Hauptverfasser: Jacque, Emilie, Schweighoffer, Edina, Visekruna, Alexander, Papoutsopoulou, Stamatia, Janzen, Julia, Zillwood, Rachel, Tarlinton, David M., Tybulewicz, Victor L.J., Ley, Steven C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172221/
https://ncbi.nlm.nih.gov/pubmed/25225457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20132019
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