Coordinate Regulation of TPL-2 and NF-κB Signaling in Macrophages by NF-κB1 p105

The role of IκB kinase (IKK)-induced proteolysis of NF-κB1 p105 in innate immune signaling was investigated using macrophages from Nfkb1(SSAA/SSAA) mice, in which the IKK target serines on p105 are mutated to alanines. We found that the IKK/p105 signaling pathway was essential for TPL-2 kinase activ...

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Main Authors: Yang, Huei-Ting, Papoutsopoulou, Stamatia, Belich, Monica, Brender, Christine, Janzen, Julia, Gantke, Thorsten, Handley, Matt, Ley, Steven C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422004/
https://ncbi.nlm.nih.gov/pubmed/22733995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00564-12
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