Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate

The MKK1/2 kinase tumour progression locus 2 (TPL-2) is critical for the production of tumour necrosis factor alpha (TNFα) in innate immune responses and a potential anti-inflammatory drug target. Several earlier pharmaceutical company screens with the isolated TPL-2 kinase domain have identified sm...

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Bibliographische Detailangaben
Veröffentlicht in:Biochem J
Hauptverfasser: Kümper, Sandra, Gantke, Thorsten, Chen, Chao-Sheng, Soneji, Yasmina, Pattison, Michael J., Chakravarty, Probir, Kjær, Svend, Thomas, Daniel, Haslam, Carl, Leavens, Bill J., House, David, Powell, David J., Ley, Steven C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2018
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5763956/
https://ncbi.nlm.nih.gov/pubmed/29229763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170579
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