Ebola virus VP35 induces high-level production of recombinant TPL-2–ABIN-2–NF-κB1 p105 complex in co-transfected HEK-293 cells

Activation of PKR (double-stranded-RNA-dependent protein kinase) by DNA plasmids decreases translation, and limits the amount of recombinant protein produced by transiently transfected HEK (human embryonic kidney)-293 cells. Co-expression with Ebola virus VP35 (virus protein 35), which blocked plasm...

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Detalhes bibliográficos
Main Authors: Gantke, Thorsten, Boussouf, Sabrina, Janzen, Julia, Morrice, Nicholas A., Howell, Steven, Mühlberger, Elke, Ley, Steven C.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2013
Assuntos:
Accelerated Publication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727213/
https://ncbi.nlm.nih.gov/pubmed/23557442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20121873
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