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Coordinate Regulation of TPL-2 and NF-κB Signaling in Macrophages by NF-κB1 p105
The role of IκB kinase (IKK)-induced proteolysis of NF-κB1 p105 in innate immune signaling was investigated using macrophages from Nfkb1(SSAA/SSAA) mice, in which the IKK target serines on p105 are mutated to alanines. We found that the IKK/p105 signaling pathway was essential for TPL-2 kinase activ...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3422004/ https://ncbi.nlm.nih.gov/pubmed/22733995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00564-12 |
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