NF-κB1 Inhibits TLR-Induced IFN-β Production in Macrophages Through TPL-2-dependent ERK Activation

Although NF-κB1 p50/p105 has critical roles in immunity, the mechanism by which NF-κB1 regulates inflammatory responses is unclear. Here, we analyzed the gene expression profile of lipopolysaccharide (LPS)-stimulated Nfkb1(−/−) macrophages that lack both p50 and p105. Deficiency of p50/p105 selectiv...

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Detalhes bibliográficos
Main Authors: Yang, Huei-Ting, Wang, Yanyan, Zhao, Xixing, Demissie, Ezana, Papoutsopoulou, Stamatia, Mambole, Agnes, O’Garra, Anne, Tomczak, Michal F., Erdman, Susan E., Fox, James G., Ley, Steven C., Horwitz, Bruce H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070925/
https://ncbi.nlm.nih.gov/pubmed/21217011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001003
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