Insufficient interleukin-12 signalling favours differentiation of human CD4(+) and CD8(+) T cells into GATA-3(+) and GATA-3(+) T-bet(+) subsets in humanized mice

Differentiation of CD4(+) T cells into type 1 or type 2 subsets is mediated by the expression of the opposing lineage defining transcription factors T-bet and GATA-3. However, the existence of GATA-3(+) T-bet(+) CD4(+) T cells in mice suggests functional plasticity of these subsets. Little is known...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Billerbeck, Eva, Labitt, Rachael N, Vega, Kevin, Frias-Staheli, Natalia, Dorner, Marcus, Xiao, Jing W, Rice, Charles M, Ploss, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2014
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172137/
https://ncbi.nlm.nih.gov/pubmed/24766459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12304
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky