Insufficient interleukin-12 signalling favours differentiation of human CD4(+) and CD8(+) T cells into GATA-3(+) and GATA-3(+) T-bet(+) subsets in humanized mice

Differentiation of CD4(+) T cells into type 1 or type 2 subsets is mediated by the expression of the opposing lineage defining transcription factors T-bet and GATA-3. However, the existence of GATA-3(+) T-bet(+) CD4(+) T cells in mice suggests functional plasticity of these subsets. Little is known...

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Sonraí Bibleagrafaíochta
Main Authors: Billerbeck, Eva, Labitt, Rachael N, Vega, Kevin, Frias-Staheli, Natalia, Dorner, Marcus, Xiao, Jing W, Rice, Charles M, Ploss, Alexander
Formáid: Artigo
Teanga:Inglês
Foilsithe: Blackwell Science Inc 2014
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Original Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172137/
https://ncbi.nlm.nih.gov/pubmed/24766459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12304
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