A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agents

A phosphine copper(I) complex [Cu(thp)(4)][PF(6)] (CP) was recently identified as an efficient in vitro antitumor agent. In this study, we evaluated the antiproliferative activity of CP in leukemia cell lines finding a significant efficacy, especially against SEM and RS4;11 cells. Immunoblot analysi...

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Main Authors: Bortolozzi, Roberta, Viola, Giampietro, Porcù, Elena, Consolaro, Francesca, Marzano, Cristina, Pellei, Maura, Gandin, Valentina, Basso, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171606/
https://ncbi.nlm.nih.gov/pubmed/24980813
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