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Hard, harder, hardest: principal stratification, statistical identifiability, and the inherent difficulty of finding surrogate endpoints

In many areas of clinical investigation there is great interest in identifying and validating surrogate endpoints, biomarkers that can be measured a relatively short time after a treatment has been administered and that can reliably predict the effect of treatment on the clinical outcome of interest...

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Detalhes bibliográficos
Main Authors: Wolfson, Julian, Henn, Lisa
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171402/
https://ncbi.nlm.nih.gov/pubmed/25342953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-7622-11-14
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