Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes

Nerve growth factor (NGF) is indispensable during normal embryonic development and critical for the amplification of pain signals in adults. Intervention in NGF signaling holds promise for the alleviation of pain resulting from human diseases such as osteoarthritis, cancer and chronic lower back dis...

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Bibliographic Details
Main Authors: La Porte, Sherry L, Eigenbrot, Charles, Ultsch, Mark, Ho, Wei-Hsien, Foletti, Davide, Forgie, Alison, Lindquist, Kevin C, Shelton, David L, Pons, Jaume
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171009/
https://ncbi.nlm.nih.gov/pubmed/24830649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.28677
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