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Pareto optimization of combinatorial mutagenesis libraries
In order to increase the hit rate of discovering diverse, beneficial protein variants via high-throughput screening, we have developed a computational method to optimize combinatorial mutagenesis libraries for overall enrichment in two distinct properties of interest. Given scoring functions for eva...
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| Vydáno v: | IEEE/ACM Trans Comput Biol Bioinform |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8262366/ https://ncbi.nlm.nih.gov/pubmed/30040654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1109/TCBB.2018.2858794 |
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