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A divide and conquer approach to determine the Pareto frontier for optimization of protein engineering experiments
In developing improved protein variants by site-directed mutagenesis or recombination, there are often competing objectives that must be considered in designing an experiment (selecting mutations or breakpoints): stability vs. novelty, affinity vs. specificity, activity vs. immunogenicity, and so fo...
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| Publicado no: | Proteins |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4939273/ https://ncbi.nlm.nih.gov/pubmed/22180081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.23237 |
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