Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes

Nerve growth factor (NGF) is indispensable during normal embryonic development and critical for the amplification of pain signals in adults. Intervention in NGF signaling holds promise for the alleviation of pain resulting from human diseases such as osteoarthritis, cancer and chronic lower back dis...

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Hlavní autoři: La Porte, Sherry L, Eigenbrot, Charles, Ultsch, Mark, Ho, Wei-Hsien, Foletti, Davide, Forgie, Alison, Lindquist, Kevin C, Shelton, David L, Pons, Jaume
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171009/
https://ncbi.nlm.nih.gov/pubmed/24830649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.28677
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