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p21(Cip) restrains hippocampal neurogenesis and protects neuronal progenitors from apoptosis during acute systemic inflammation: Inflammation-induced p21 restrains hippocampal neurogenesis
Altered neurogenesis in adult hippocampus is implicated in cognition impairment and depression. Inflammation is a potent inhibitor of neurogenesis. The cyclin-dependent kinase inhibitor p21(Cip1) (p21) restrains cell cycle progression and arrests the cell in the G1 phase. We recently showed that p21...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4170945/ https://ncbi.nlm.nih.gov/pubmed/23966332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hipo.22192 |
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