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p21(Cip) restrains hippocampal neurogenesis and protects neuronal progenitors from apoptosis during acute systemic inflammation: Inflammation-induced p21 restrains hippocampal neurogenesis

Altered neurogenesis in adult hippocampus is implicated in cognition impairment and depression. Inflammation is a potent inhibitor of neurogenesis. The cyclin-dependent kinase inhibitor p21(Cip1) (p21) restrains cell cycle progression and arrests the cell in the G1 phase. We recently showed that p21...

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Détails bibliographiques
Auteurs principaux: Zonis, Svetlana, Ljubimov, Vladimir A., Mahgerefteh, Michael, Pechnick, Robert N., Wawrowsky, Kolja, Chesnokova, Vera
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170945/
https://ncbi.nlm.nih.gov/pubmed/23966332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hipo.22192
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