Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

The retinoblastoma susceptibility gene (Rb) participates in controlling the G1/S-phase transition, presumably by binding and inactivating E2F transcription activator family members. Mouse embryonic fibroblasts (MEFs) with no, one, or two inactivated Rb genes were used to determine the specific contr...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Almasan, A, Yin, Y, Kelly, R E, Lee, E Y, Bradley, A, Li, W, Bertino, J R, Wahl, G M
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1995
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41709/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7777526/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.12.5436
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