Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

The retinoblastoma susceptibility gene (Rb) participates in controlling the G1/S-phase transition, presumably by binding and inactivating E2F transcription activator family members. Mouse embryonic fibroblasts (MEFs) with no, one, or two inactivated Rb genes were used to determine the specific contr...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Almasan, A, Yin, Y, Kelly, R E, Lee, E Y, Bradley, A, Li, W, Bertino, J R, Wahl, G M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41709/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7777526/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.12.5436
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