Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

The retinoblastoma susceptibility gene (Rb) participates in controlling the G1/S-phase transition, presumably by binding and inactivating E2F transcription activator family members. Mouse embryonic fibroblasts (MEFs) with no, one, or two inactivated Rb genes were used to determine the specific contr...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Almasan, A, Yin, Y, Kelly, R E, Lee, E Y, Bradley, A, Li, W, Bertino, J R, Wahl, G M
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1995
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41709/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7777526/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.12.5436
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