Chargement en cours...
Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway
Usp5 is a deubiquitinase (DUB) previously shown to regulate unanchored polyubiquitin (Ub) chains, p53 transcriptional activity and double-strand DNA repair. In BRAF mutant melanoma cells, Usp5 activity was suppressed by BRAF inhibitor (vemurafenib) in sensitive but not in acquired or intrinsically r...
Enregistré dans:
| Auteurs principaux: | , , , , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Impact Journals LLC
2014
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4170643/ https://ncbi.nlm.nih.gov/pubmed/24980819 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|