Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway

Usp5 is a deubiquitinase (DUB) previously shown to regulate unanchored polyubiquitin (Ub) chains, p53 transcriptional activity and double-strand DNA repair. In BRAF mutant melanoma cells, Usp5 activity was suppressed by BRAF inhibitor (vemurafenib) in sensitive but not in acquired or intrinsically r...

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Autors principals: Potu, Harish, Peterson, Luke F., Pal, Anupama, Verhaegen, Monique, Cao, Juxiang, Talpaz, Moshe, Donato, Nicholas J.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170643/
https://ncbi.nlm.nih.gov/pubmed/24980819
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