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Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma
Melanoma tumors driven by BRAF mutations often do not respond to BRAF/MEK/ERK pathway inhibitors currently used in treatment. One documented mechanism of resistance is upregulation of SOX2, a transcription factor that is essential for tumor growth and expansion, particularly in melanoma tumors with...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7869572/ https://ncbi.nlm.nih.gov/pubmed/33613844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27869 |
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