The UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms

Sensing of nucleic acids by TLRs is crucial in the host defense against viruses and bacteria. Unc-93 homolog B1 (UNC93B1) regulates the trafficking of nucleic acid sensing TLRs from the ER to endolysosomes, where the TLRs encounter their respective ligands and become activated. Here we show that a c...

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Main Authors: Pelka, Karin, Phulphagar, Kshiti, Zimmermann, Jana, Stahl, Rainer, Schmid-Burgk, Jonathan L., Schmidt, Tobias, Spille, Jan-Hendrik, Labzin, Larisa I., Agrawal, Sudhir, Kandimalla, Ekambar, Casanova, Jean-Laurent, Hornung, Veit, Marshak-Rothstein, Ann, Höning, Stefan, Latz, Eicke
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170058/
https://ncbi.nlm.nih.gov/pubmed/25187660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301886
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