The chaperone UNC93B1 regulates toll-like receptor stability independent of endosomal TLR transport

Unc-93 homolog B1 (UNC93B1) is a key regulator of nucleic acid (NA)-sensing toll-like receptors (TLRs). Loss of NA-sensing TLR responses in UNC93B1-deficient patients facilitates HSV-1 encephalitis. UNC93B1 is thought to guide NA-sensing TLRs from the endoplasmic reticulum (ER) to their respective e...

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Pubblicato in:Immunity
Autori principali: Pelka, Karin, Bertheloot, Damien, Reimer, Elisa, Phulphagar, Kshiti, Schmidt, Susanne V., Christ, Anette, Stahl, Rainer, Watson, Nicki, Miyake, Kensuke, Hacohen, Nir, Haas, Albert, Brinkmann, Melanie M., Marshak-Rothstein, Ann, Meissner, Felix, Latz, Eicke
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482051/
https://ncbi.nlm.nih.gov/pubmed/29768176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.04.011
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