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A major deletion in the Vκ-Jκ intervening region results in hyper-elevated transcription of proximal Vκ genes and a severely restricted repertoire()
Our previous studies have shown that DNase I hypersensitive sites HS1-2 and HS3-6 within the mouse Vκ–Jκ intervening region are essential for controlling locus contraction and creating a diverse antibody repertoire. Here we demonstrate that a 6.3 kb deletion encompassing HS1-6 altogether not only le...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4170056/ https://ncbi.nlm.nih.gov/pubmed/25187654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401574 |
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