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Proper orientation of CTCF sites in Cer is required for normal Jκ-distal and proximal Vκ gene usage
Igκ locus contraction and Vκ gene usage are controlled by Cer, a cis-acting sequence in the Vκ-Jκ intervening region. This effect is attributed to two CTCF binding sites within Cer that are oriented towards the Vκ gene region. However, the importance of Cer CTCF orientation in regulating VκJκ rearra...
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| Vydáno v: | J Immunol |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6125182/ https://ncbi.nlm.nih.gov/pubmed/30076197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800785 |
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