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Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

[Image: see text] Inhibition of histone demethylases has within recent years advanced into a new strategy for treating cancer and other diseases. Targeting specific histone demethylases can be challenging, as the active sites of KDM1A-B and KDM4A-D histone demethylases are highly conserved. Most inh...

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Main Authors: Leurs, Ulrike, Lohse, Brian, Rand, Kasper D., Ming, Shonoi, Riise, Erik S., Cole, Philip A., Kristensen, Jesper L., Clausen, Rasmus P.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2014
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168794/
https://ncbi.nlm.nih.gov/pubmed/25014588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500374f
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