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Treatment of glioblastoma multiforme using combination of siRNA targeting EGFR and β-catenin

BACKGROUND: EGFR and β-catenin are two key mediators of cell signal transduction implicated in the pathogenesis of a variety of tumors. There is emerging evidence indicating that they are overexpressed in glioblastoma multiforme (GBM) and both play significant roles in GBM carcinogenesis. Moreover,...

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Detalles Bibliográficos
Main Authors: Wang, Kui, Park, James O., Zhang, Miqin
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167580/
https://ncbi.nlm.nih.gov/pubmed/23319157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.2693
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