Active Site Coupling in PDE:PKA Complexes Promotes Resetting of Mammalian cAMP Signaling

Cyclic 3′5′ adenosine monophosphate (cAMP)-dependent-protein kinase (PKA) signaling is a fundamental regulatory pathway for mediating cellular responses to hormonal stimuli. The pathway is activated by high-affinity association of cAMP with the regulatory subunit of PKA and signal termination is ach...

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Bibliographic Details
Main Authors: Krishnamurthy, Srinath, Moorthy, Balakrishnan Shenbaga, Xin Xiang, Lim, Xin Shan, Lim, Bharatham, Kavitha, Tulsian, Nikhil Kumar, Mihalek, Ivana, Anand, Ganesh S.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2014
Subjects:
Proteins and Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167538/
https://ncbi.nlm.nih.gov/pubmed/25229150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.07.050
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