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Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis
BACKGROUND: Abnormal tau hyperphosphorylation and its accumulation into intra-neuronal neurofibrillary tangles are linked to neurodegeneration in Alzheimer’s disease and similar tauopathies. One strategy to reduce accumulation is through immunization, but the most immunogenic tau epitopes have so fa...
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Auteurs principaux: | , , , , , , , , , , , , |
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Format: | Artigo |
Langue: | Inglês |
Publié: |
BioMed Central
2014
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Sujets: | |
Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4167523/ https://ncbi.nlm.nih.gov/pubmed/25183004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-014-0152-0 |
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