Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis

BACKGROUND: Abnormal tau hyperphosphorylation and its accumulation into intra-neuronal neurofibrillary tangles are linked to neurodegeneration in Alzheimer’s disease and similar tauopathies. One strategy to reduce accumulation is through immunization, but the most immunogenic tau epitopes have so fa...

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Hlavní autoři: Selenica, Maj-Linda B, Davtyan, Hayk, Housley, Steven B, Blair, Laura J, Gillies, Anne, Nordhues, Bryce A, Zhang, Bo, Liu, Joseph, Gestwicki, Jason E, Lee, Daniel C, Gordon, Marcia N, Morgan, Dave, Dickey, Chad A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167523/
https://ncbi.nlm.nih.gov/pubmed/25183004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-014-0152-0
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