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Experimental manipulations of microglia in mouse models of Alzheimer’s pathology. Activation reduces amyloid but hastens tau pathology

The inflammation hypothesis of Alzheimer’s pathogenesis has directed much scientific effort towards ameliorating this disease. The development of mouse models of amyloid deposition permitted direct tests of the proposal that amyloid-activated microglia could cause neurodegeneration in vivo. Many app...

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Detalles Bibliográficos
Publicado en:Neuropathol Appl Neurobiol
Autores principales: Lee, Daniel C., Rizer, Justin, Hunt, Jerry B., Selenica, Maj-Linda B., Gordon, Marcia N., Morgan, Dave
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300851/
https://ncbi.nlm.nih.gov/pubmed/23171029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nan.12002
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