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Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how subthreshold risk loci translate into relevant disease pathways is unknown. We investigate here the involvement of A...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:EMBO Mol Med
मुख्य लेखकों: Sierksma, Annerieke, Lu, Ashley, Mancuso, Renzo, Fattorelli, Nicola, Thrupp, Nicola, Salta, Evgenia, Zoco, Jesus, Blum, David, Buée, Luc, De Strooper, Bart, Fiers, Mark
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: John Wiley and Sons Inc. 2020
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059012/
https://ncbi.nlm.nih.gov/pubmed/31951107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910606
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