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Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how subthreshold risk loci translate into relevant disease pathways is unknown. We investigate here the involvement of A...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Sierksma, Annerieke, Lu, Ashley, Mancuso, Renzo, Fattorelli, Nicola, Thrupp, Nicola, Salta, Evgenia, Zoco, Jesus, Blum, David, Buée, Luc, De Strooper, Bart, Fiers, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059012/
https://ncbi.nlm.nih.gov/pubmed/31951107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910606
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