LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

Inflammation and microglial activation are associated with Alzheimer's disease (AD) pathology. Somewhat surprisingly, injection of a prototypical inflammatory agent, lipopolysaccharide (LPS) into brains of amyloid precursor protein (APP) transgenic mice clears some of the pre-existing amyloid d...

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Bibliografiske detaljer
Main Authors: Lee, Daniel C, Rizer, Justin, Selenica, Maj-Linda B, Reid, Patrick, Kraft, Clara, Johnson, Amelia, Blair, Laura, Gordon, Marcia N, Dickey, Chad A, Morgan, Dave
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949628/
https://ncbi.nlm.nih.gov/pubmed/20846376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-7-56
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