Chromosomal instability selects gene copy number variants encoding core regulators of proliferation in ER+ breast cancer

Chromosomal instability (CIN) is associated with poor outcome in epithelial malignancies including breast carcinomas. Evidence suggests that prognostic signatures in estrogen receptor-positive (ER+) breast cancer define tumors with CIN and high proliferative potential. Intriguingly, CIN induction in...

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Bibliographische Detailangaben
Hauptverfasser: Endesfelder, David, Burrell, Rebecca, Kanu, Nnennaya, McGranahan, Nicholas, Howell, Mike, Parker, Peter J., Downward, Julian, Swanton, Charles, Kschischo, Maik
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167338/
https://ncbi.nlm.nih.gov/pubmed/24970479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2664
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