Systemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells

Whole brain radiation therapy (WBRT) induces profound cerebral microvascular rarefaction throughout the hippocampus. Despite the vascular loss and localized cerebral hypoxia, angiogenesis fails to occur, which subsequently induces long-term deficits in learning and memory. The mechanisms underlying...

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Bibliographic Details
Main Authors: Ashpole, Nicole M., Warrington, Junie P., Mitschelen, Matthew C., Yan, Han, Sosnowska, Danuta, Gautam, Tripti, Farley, Julie A., Csiszar, Anna, Ungvari, Zoltan, Sonntag, William E.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
Subjects:
Vascular Biology and Microcirculation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166745/
https://ncbi.nlm.nih.gov/pubmed/25038144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00308.2014
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