Systemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells

Whole brain radiation therapy (WBRT) induces profound cerebral microvascular rarefaction throughout the hippocampus. Despite the vascular loss and localized cerebral hypoxia, angiogenesis fails to occur, which subsequently induces long-term deficits in learning and memory. The mechanisms underlying...

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Autors principals: Ashpole, Nicole M., Warrington, Junie P., Mitschelen, Matthew C., Yan, Han, Sosnowska, Danuta, Gautam, Tripti, Farley, Julie A., Csiszar, Anna, Ungvari, Zoltan, Sonntag, William E.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2014
Matèries:
Vascular Biology and Microcirculation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166745/
https://ncbi.nlm.nih.gov/pubmed/25038144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00308.2014
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