Programmed death-1 expression on HIV-1-specific CD8(+) T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

OBJECTIVES: Although CD8(+) T cells play a critical role in the control of HIV-1 infection, their antiviral efficacy can be limited by antigenic variation and immune exhaustion. The latter phenomenon is characterized by the upregulation of multiple inhibitory receptors, such as programmed death-1 (P...

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Библиографические подробности
Главные авторы: Kløverpris, Henrik N., McGregor, Reuben, McLaren, James E., Ladell, Kristin, Stryhn, Anette, Koofhethile, Catherine, Brener, Jacqui, Chen, Fabian, Riddell, Lynn, Graziano, Luzzi, Klenerman, Paul, Leslie, Alasdair, Buus, Søren, Price, David A., Goulder, Philip
Формат: Artigo
Язык:Inglês
Опубликовано: Lippincott Williams & Wilkins 2014
Предметы:
Basic Science
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166042/
https://ncbi.nlm.nih.gov/pubmed/24906112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000000362
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