PTEN action in leukemia dictated by the tissue microenvironment

PTEN encodes a lipid phosphatase that is underexpressed in many cancers owing to deletions, mutations or gene silencing(1–3). PTEN dephosphorylates phosphatidylinositol 3,4,5-triphosphate (PIP(3)), thereby opposing the activity of class I phosphatidylinositol 3-kinases (PI3Ks) that mediate growth an...

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Bibliografiske detaljer
Main Authors: Miething, Cornelius, Scuoppo, Claudio, Bosbach, Benedikt, Appelmann, Iris, Nakitandwe, Joy, Ma, Jing, Wu, Gang, Lintault, Laura, Auer, Martina, Premsrirut, Prem K., Teruya-Feldstein, Julie, Hicks, James, Benveniste, Helene, Speicher, Michael R., Downing, James R., Lowe, Scott W.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165899/
https://ncbi.nlm.nih.gov/pubmed/24805236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13239
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