SENP1 regulates PTEN stability to dictate prostate cancer development

SUMO protease SENP1 is elevated in multiple carcinomas including prostate cancer (PCa). SENP1 exhibits carcinogenic properties; it promotes androgen receptor-dependent and -independent cell proliferation, stabilizes HIF1a, increases VEGF, and supports angiogenesis. However, mice expressing an androg...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bawa-Khalfe, Tasneem, Yang, Feng-Ming, Ritho, Joan, Lin, Hui-Kuan, Cheng, Jinke, Yeh, Edward T.H.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392276/
https://ncbi.nlm.nih.gov/pubmed/27852060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13283
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